According to Sportsbook Review, Denver comes into Lucas Oil Stadium as 2.5-point favorites on Thursday Night Football even though there are many factors that favor the Colts in this matchup.
Indianapolis has the home-field advantage, which may not be worth the full 3 points as is customary in the NFL because of their disappointing season, but a primetime game should provide a hostile atmosphere for the visiting Broncos.
The Colts also have the advantage of being at home on a short week as Denver is forced to cut their preparation short before traveling to Indy.